Update: Study Compares Aspirin to Other Anticoagulants to Prevent VTE Prophylaxis Following Joint Replacement
A systematic review and meta-analysis published online in JAMA Internal Medicine compared the effectiveness of aspirin versus other anticoagulants in preventing postoperative venous thromboembolism (VTE) prophylaxis in total hip replacement (THR) and total knee replacement (TKR) patients. Randomized, controlled trials (RCTs) were identified through searches of the MEDLINE, Embase, Web of Science, and Cochrane Library databases, as well as bibliographic searches. Search terms were related to the population, drug intervention, and outcome. Final analysis included 13 RCTs encompassing 6,060 total patients (mean age, 63.0 years; 57.2 percent were female). The relative risk (RR) of postoperative VTE for aspirin, compared to other anticoagulants, was 1.12; results were similar for deep vein thrombosis (DVT) (RR = 1.04) and pulmonary embolism (PE) (RR = 1.01). The use of aspirin versus other anticoagulants did not largely impact adverse event risk. Separate analyses of THRs and TKRs did not yield significant differences in VTE, DVT, and PE risks between aspirin versus other anticoagulants. Evidence ranged from low to high quality. The study authors concluded that the effectiveness of aspirin was comparable to that of other anticoagulants and recommended that future studies include a noninferiority analysis of aspirin compared to alternative anticoagulants and cost-effectiveness. [This is an update to a previous summary included in Headline News Now. Thank you to David C. Ring, MD, PhD, for his feedback.]