Today’s Top Story

Study Evaluates Tanezumab Efficacy and Safety in Hip and Knee OA

A randomized clinical trial published online in JAMA found that tanezumab may improve pain and physical function in patients with osteoarthritis (OA) of the hip and knee but could increase the risks for joint safety events and total joint replacement (TJR). Patients were stratified into three treatment groups: tanezumab 2.5 mg at day one and week eight (n = 231), tanezumab 2.5 mg at day one and 5 mg at week eight (tanezumab 2.5/5 mg, n = 233), or placebo at day one and week eight (n = 232). In total, 582 patients completed the trial. Compared to the placebo group, patients receiving both doses of tanezumab had better improvements in mean Western Ontario and McMasters Universities Osteoarthritis Index Pain and Physical Function scores, as well as patient global assessment of OA score. Rapidly progressive OA was observed in 2.2 percent of the tanezumab 2.5 mg group and 0.4 percent of the tanezumab 2.5/5 mg group. TJR incidence was 3.5 percent in the tanezumab 2.5 mg group, 6.9 percent in the tanezumab 2.5/5 mg group, and 1.7 percent in the placebo group.

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In Other News

Study Measures Complications in Arthroscopic RCR Patients with Obstructive Sleep Apnea

Patients with obstructive sleep apnea (OSA) who undergo arthroscopic rotator cuff repair (RCR) may have greater risks of postoperative emergency department (ED) visits and hospital admissions, according to a study published in the July 1 issue of the Journal of the AAOS. Researchers conducted a database search of RCR patients with and without OSA; data were further stratified by patients with and without a continuous positive airway pressure (CPAP) device billing code. OSA patients were significantly more likely to have postoperative ED visits and hospital admission. Patients with CPAP orders decrease their risks for ED visits, hospital admissions, and respiratory complications.

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Study Assesses Long-term Outcomes of Dislocated Radial Fractures with Concomitant Intracarpal Lesions

A study published in the June issue of the Archives of Orthopaedic and Trauma Surgery evaluated how concomitant carpal lesions impact patients with dislocated radial fracture (DRF) after 10 years. The study included 104 consecutive DRF patients who underwent a preoperative morphological CT and MRI scan. One-year follow-up found no association between the carpal lesions and treatment outcome. After 10 years, 37 patients were available for follow-up; there was still no association between the concomitant lesions and treatment outcome.

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Study: BMD and Strength in Prostate Cancer Patients Treated with Androgen Deprivation Therapy

Patients with advanced prostate cancer who undergo androgen deprivation therapy (ADT) may have lower bone mineral density (BMD) and compressive bone strength, according to a study published online in Bone. The study compared prostate cancer patients treated with ADT (n = 70) to two control groups: prostate cancer patients not treated with ADT (n = 52) and healthy patients (n = 70). All patients were evaluated for dual-energy X-ray absorptiometry lumbar spine and proximal femur areal BMD (aBMD) and peripheral quantitative CT distal (4 percent) and proximal (66 percent) tibia and radius cortical and trabecular volumetric BMD (vBMD), bone structure, strength, and cortical bone distribution. The ADT group had 7.2 percent to 7.8 percent lower lumbar spine aBMD than both control groups; a trend was observed for lower total hip aBMD in the ADT group. Compared to both control cohorts, the ADT group had greater total bone area at the distal tibia (6.2 percent to 7.3 percent) but lower total vBMD (8.4 percent to 8.7 percent). Compared only to the healthy controls, the ADT group had 10.8 percent lower relative bone strength index (BSI). The ADT cohort had lower total and trabecular vBMD (10.7 percent to 14.8 percent) and BSI (23.6 percent to 27.5 percent) than both control groups.

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Consolidation Causes Concerns for Health Costs

As policymakers attempt to increase healthcare competition to drive down costs, a significant focus has been placed on the regulation of hospitals and insurers purchasing physician practices. In light of numerous recent antitrust actions in response to this practice, there is concern about the impact consolidation will have on the already rising prices and total spending in health care.

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Read more on AAOS’ efforts to preserve choice and competition…(member login required)


July AAOS Now Is Now Available Online

AAOS members will soon receive the print edition of the July issue of AAOS Now, but the electronic edition is already available on the AAOS Now website and on iOS and Android devices through the AAOS Access app. This month’s issue highlights the latest advancements in hip arthroscopy and hip preservation, the Academy’s new core values, domestic medical tourism, and more.

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The Academy Introduces a New AAOS Now

The American Academy of Orthopaedic Surgeons recently unveiled significant redesigns for the print and digital versions of its monthly magazine AAOS Now. The site,, enables users to quickly find the content they want with minimal effort. The landing page showcases the most current news segmented by department. In addition, the streamlined menu navigation allows users to quickly access content segmented by orthopaedic specialties by simply clicking the subspecialty tab. To find and access even more specific content, a robust search tool spans AAOS Now articles going back to 2007. Content can be filtered by date, relevancy, department, subspecialty, issue year, and issue month. We hope you enjoy the new


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